GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BRCA | cis | rs2382817 | 1 | rs10932772 | chr2:219177148 | TMBIM1 | chr2:219138917-219157280:- | 0.17 | 5.02 | 6.09E-7 | Crohn's disease;Ulcerative colitis;Inflammatory bowel disease |
| BRCA | cis | rs2087017 | 1 | rs10934254 | chr3:113841634 | GRAMD1C | chr3:113547029-113666020:+ | -0.12 | -3.64 | 0.00029 | Personality dimensions |
| BRCA | cis | rs2087017 | 1 | rs10934255 | chr3:113842444 | GRAMD1C | chr3:113547029-113666020:+ | -0.12 | -3.65 | 0.000277 | Personality dimensions |
| BRCA | cis | rs10935120 | 1 | rs10935120 | chr3:134233092 | ANAPC13 | chr3:134196547-134204865:- | -0.4 | -13.33 | 1.33E-37 | Height |
| BRCA | cis | rs10935120 | 1 | rs10935120 | chr3:134233092 | CEP63 | chr3:134204575-134293852:+ | -0.16 | -4.36 | 1.44E-5 | Height |
| BRCA | cis | rs7432375 | 1 | rs10935186 | chr3:136346206 | PCCB | chr3:135969167-136056737:+ | 0.14 | 3.8 | 0.000156 | Schizophrenia |
| BRCA | cis | rs7637404 | 1 | rs10937463 | chr3:190985247 | UTS2D | chr3:190984945-191048325:- | 0.23 | 6.65 | 4.77E-11 | Age-related hearing impairment (interaction) |
| BRCA | cis | rs7637404 | 1 | rs10937464 | chr3:190985274 | UTS2D | chr3:190984945-191048325:- | -0.22 | -6.45 | 1.66E-10 | Age-related hearing impairment (interaction) |
| BRCA | cis | rs7637404 | 1 | rs10937465 | chr3:190985279 | UTS2D | chr3:190984945-191048325:- | -0.22 | -6.45 | 1.66E-10 | Age-related hearing impairment (interaction) |
| BRCA | cis | rs10938353 | 1 | rs10938353 | chr4:44582487 | GUF1 | chr4:44680433-44702696:+ | -0.16 | -3.97 | 7.63E-5 | Body mass index |
| BRCA | cis | rs1008375 | 1 | rs10939740 | chr4:17617490 | MED28 | chr4:17616273-17629791:+ | 0.14 | 3.69 | 0.000234 | Parasitemia in Tripanosoma cruzi seropositivity |
| BRCA | cis | rs1577917 | 1 | rs10944161 | chr6:86630376 | SNHG5 | chr6:86386726-86388451:- | -0.56 | -17.95 | 3.91E-63 | Response to antipsychotic treatment |
| BRCA | cis | rs1577917 | 1 | rs10944169 | chr6:86683036 | SNHG5 | chr6:86386726-86388451:- | -0.58 | -18.24 | 6.52E-65 | Response to antipsychotic treatment |
| BRCA | cis | rs1577917 | 1 | rs10944170 | chr6:86685469 | SNHG5 | chr6:86386726-86388451:- | -0.57 | -17.82 | 2.27E-62 | Response to antipsychotic treatment |
| BRCA | cis | rs12216499 | 1 | rs10945582 | chr6:159381088 | RSPH3 | chr6:159398268-159421198:- | -0.19 | -3.42 | 0.00064 | Bladder cancer (smoking interaction) |